Farber disease or Farber lipogranulomatosis (OMIM #228000) is a genetic disorder with autosomal recessive inheritance that is caused by mutations in the gene encoding acid ceramidase (ASAH1) on chromosome 8p22, the enzyme, which is responsible for the degradation of ceramide into sphingosine and free fatty acids (Table 1). This evidence concerns the gene ASAH1 and Farber lipogranulomatosis.