Since the discovery of DISC1 as a susceptibility gene for mental disorders, several groups have directed their efforts into creating animal models for these diseases based upon DISC1 modifications per se (Arguello and Gogos, 2006; Jaaro-Peled, 2009; Pletnikov, 2009) or in combination with environmental factors such as stress (Cash-Padgett and Jaaro-Peled, 2013). The gene discussed is DISC1; the disease is psychiatric disorder.