MAPT and Alzheimer disease: Since there is a clear relationship between neuropathological signs (amyloid plaques and tau tangles) in the prefrontal cortex (PreF) and mesial-temporal (T) lobe and reduced cognitive performance in AD, the emergence of FC alterations in regions classically devoid of neuropathological alterations (e.g., several other cortical areas and the cerebellum) is puzzling.