The pathological hallmarks of AD are the accumulation of β amyloid (Aβ1–42) plaques and tau tangles concentrated in the prefrontal and mesial-temporal lobe (Blennow et al., 2006; Holtzman et al., 2011; Serrano-Pozo et al., 2011; Herskovits et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.