ANKRD11 and Cornelia de Lange syndrome: This girl had an atypical CdLS-like phenotype, but notably had a normal head circumference (OFC=−0.27 SD) as did the boy mentioned above with the intragenic deletion in ANKRD11. We, therefore, sequenced the coding and splice regions of ANKRD11 in 10 further individuals with reported OFC ≥−2.0 SD.