Moreover, the regulation of c-Myc by miR-145 has been associated with proliferation, apoptosis and metastasis in various cancers, including colon cancer, NSCLC, ovarian cancer, breast cancer, oesophageal and oral squamous cell carcinoma 66,109,111–114, highlighting the potent tumour-suppressive effect of the miR-145/c-Myc pathway. This evidence concerns the gene MYC and malignant colon neoplasm.