CASP3 and malignant colon neoplasm: MiR-145 induces caspase-3-dependent apoptosis in colon cancer by targeting DNA fragmentation factor 45 (DFF45), which is the substrate of caspase-3 and whose cleavage by caspase-3 during apoptosis releases DFF40, which degrades chromosomal DNA into nucleosomal fragments 88.