Moreover, miR-145 directly targets catenin δ-1 and impairs nuclear translocation of β-catenin by disturbing the nuclear import of p21-activated kinase 4 (PAK4), leading to the down-regulation of downstream target genes c-Myc and CyclinD1, which contribute to the attenuation of cell migration and invasion activities in colon cancer 150. Here, PAK4 is linked to colonic neoplasm.