POLE and colorectal carcinoma: To conclude, we show that the frequency of POLE mutations in MSS CRC is considerably higher than previously reported including splice-site, truncating and double mutations and provide evidence that albeit biologically different from the other molecular subtypes, POLE mutated CRCs in general do not appear to constitute an entirely new entity from the clinical viewpoint, since they lacks specific features that allow for a separation of these tumors from the whole class of CRC in terms of epidemiology and outcome.