COL4A1 and early-onset non-syndromic cataract: Congenital or early onset of cataract has previously been observed in patients with mutations in COL4A1[16],[17], whereas congenital cataracts were always associated with multi-system disorders, along with cerebrovascular disease (brain small vessel disease and intracerebral hemorrhage), nephropathy, muscle cramps, and ocular anomalies.