These studies confirmed recurrent mutations in the chromatin-modulating genes polybromo 1 (PBRM1) [16], SET domain containing 2 (SETD2) [17, 18], BRCA1-associated protein-1 (BAP1) [19], and lysine (K)-specific demethylase 5C (KDM5C) [17] in kidney cancer. The gene discussed is SETD2; the disease is kidney cancer.