STAT3 and familial pancreatic carcinoma: For example, Zhao et al. demonstrated that the deregulated expression of miR-130b was associated with poor prognosis and aggressive phenotype of pancreatic cancer, and miR-130b played an important role in the regulation of pancreatic cancer malignant behavior including cell proliferation and invasion by directly targeting STAT3, indicating that miR-130b might be applied as a potential prognostic biomarker and inhibitor in pancreatic cancer [22].