EZH2 and diffuse large B-cell lymphoma: We also found one late-divergent mode patient (pair 8, sample ID 14R) with relapse-specific EZH2Y641 mutation (Figure 2A), indicating that relapse DLBCL can also acquire new EZH2 mutations and that, in addition to its roles in initiating and maintaining DLBCL [21], mutant EZH2 may also contribute to disease relapse.