We found that overall relapse samples gained coding region nonsynonymous SNVs in 305 genes, among which only 71 were mutated in other previously reported primary DLBCL genomic sequencing studies, including BCL2, EP300, KMT2D, MYC, TET2, and TNFRSF14 [17–20]. Here, KMT2D is linked to diffuse large B-cell lymphoma.