Moreover, because of the importance of calcium-dependent regulation of NFAT and NF-κB activities in the determination of cell-fate choice of B cells during humoral immune responses, and the chronic activation of B-cell receptor signaling and elevated calcium signaling in aggressive Activated B-cell-like DLBCL [46], it would be interesting to further investigate the role of this pathway in the DLBCL relapse process and develop targeted therapy against this pathway to treat relapse DLBCL. Here, NFKB1 is linked to diffuse large B-cell lymphoma.