PHACTR1 and coronary artery disorder: Three genetic variants connected with phosphatase are shown to be associated with the risk of CAD [6,7], including rs12526453 of PHACTR1, rs3828329 of ACP1 and rs11066301 of PTPN11. The PHACTR1 gene encodes the protein phosphatase 1 and actin regulator 1 (PHACTR1), an enzyme regulating endothelial nitricoxide in humans [8].