BCHE and Alzheimer disease: Acetylcholinesteraseand butyrylcholinesterase (a coregulator of cholinergic neurotransmission) are markers used todifferentiate anterior thalamic nuclei (Darvesh et al. 2003).Acetylcholinesterase is found in the highest concentrations in axons in the AD and AV, whilebutyrylcholinesterase is more concentrated in neurons in AD and latero-dorsal thalamic nucleus(Robertson et al. 1986; Tagoet al. 1992).