HTT and Huntington disease: For example, the oral administration of trehalose counteracted polyQ toxicity and ameliorated the phenotype, improving motor dysfunction and extended life span in a mouse model of Huntington disease (HD) (43); trehalose administration resulted in a decrease of aggregation of huntingtin mutant protein in several brain areas (but also in liver), thus even when administered orally, it can be adsorbed and a fraction non metabolized in the gastrointestinal tract, can cross the brain blood barrier reaching the neuronal cells affected in HD (43).