WT mouse GMCs infected with AD-EP4 are stimulated with 10 ng/ml TGF-β1 for 24 h, inducing a significant increase in FN, Col I expression compared with those of TGF-β1 treated AD-GFP infected controls (P<0.05) (Fig. 4B). The gene discussed is TGFB1; the disease is Alzheimer disease.