These include previously identified HIF-1 target genes such as ANKRD37[47], STC-2[51], and STC-1[52], [48], as well as COL5A1 induced by hypoxia in the ventricle [53], ZNF395 regulated by hypoxia in glioblastoma [54], and TMEM45 in hematopoietic stem cells [55]. This evidence concerns the gene COL5A1 and glioblastoma.