CXCR4 and cancer: Among them, numerous genes are known to be related to carcinogenesis and/or tumor progression such as BRAF (the main oncogene in melanoma), NEDD9, LOX, CXCR4 (related to cancer spreading), DNA repair genes (BRCA1 and BRCA2), angiogenesis regulators (ADM, ANG, and ANGPTL4), and cancer suppressor genes (NME1 and WISP2).