The analysis of selected gene sets (289) confirmed that transcripts linked to the NFκB, AP1, as well as VEGF and EGF signaling pathways were more affected by cycling hypoxia than chronic hypoxia in ovarian and prostate cancer cells; while those related to immune response and replication were preferentially affected in melanoma cells exposed to cycling hypoxia. The gene discussed is VEGFA; the disease is Familial prostate cancer.