As shown in Figure 10, its cardioprotective efficacy is a comprehensive results by different pathway in a synergistic manner, including restoration of Ang II-NADPHoxidase-ROS-MMPs pathways and reduction of both TNF-α-NF-κB and IL-6-STAT3 pathways, thus to restore the hemodynamic parameters, normalize the cardiac function, and provide the comprehensive cardiac protective efficacy to HF. This evidence concerns the gene STAT3 and hydrops fetalis.