KLK3 and bone metastasis: After adjustment for various parameters, including age and BMI in model 1; prostate volume, Gleason score, bone metastasis, and pathologic bone fracture in model 2; and hemoglobin at diagnosis, baseline hypertension, diabetes mellitus, cerebrovascular incident, history of coronary artery disease, and Charlson index in model 3, the OR indicates a significantly higher rate of BCP in the high initial PSA group (P<0.001).