FLCN and Birt-Hogg-Dube syndrome: Fnip1−/− mice develop normally and do not develop renal tumors (Baba et al. 2012), while Bhd−/− embryos die at embryonic day 5.5 (Hasumi et al. 2009; Cash et al. 2011) and Bhd+/− mice develop oncocytic renal tumors that resemble those in BHD patients (Hartman et al. 2009).