FLCN and Birt-Hogg-Dube syndrome: Because all cells in Bhd+/− mice have inactivation of one allele of the Bhd gene, as do BHD patients, the impact of FLCN deficiency in this model could involve not only cell–cell adhesion and cellular signaling between the haploinsufficient cells of the lung epithelium but also lung capillary endothelial cells.