The function of FHL2 in cancers is particularly intriguing because FHL2 can function as an oncoprotein or as a tumor suppressor [6] in different type of cancers, including prostate cancer [7], liver cancer [8], [9], gastrointestinal cancers [10]–[12], breast cancer [13] and osteosarcoma [14]. Here, FHL2 is linked to osteosarcoma.