To determine population kinetics and cytokine production by TEFF cells in lymphoid and peripheral tissues, we utilized a skin infection with HSV-1 in combination with adoptive transfer of TCR-transgenic T cells specific for determinants derived from the HSV glycoproteins gB (CD8+ gBT-I cells) [31] and gD (CD4+ gDT-II cells) [4], respectively. The gene discussed is CD4; the disease is skin infection.