Thirdly, depletion of p27Kip1 in p27Kip1-expressing MEFs results in a dramatic up-regulation of EGFR expression, suggesting that p27Kip1-regulated EGFR expression is not only operative in bladder cancer cells, but also in non-bladder cancer and non-cancer cells. This evidence concerns the gene CDKN1B and urinary bladder carcinoma.