They performed in vitro and in vivo experiments showing that overexpression of this enzyme increases malignant phenotype of colon cancer cells, and these phenotypic changes are associated with enhanced integrin and mitogen-activated protein kinase (MAPK) signaling, suggesting that B4GALNT3 may play a crucial role in promoting malignant behavior of colon cancer (140). This evidence concerns the gene WNK2 and malignant colon neoplasm.