In two different studies undertaken in Ghana and Mali, IL-10 responses to malaria antigen were found to be higher in helminth and malaria co-infected subjects (Hartgers et al. 2009; Lyke et al. 2012) whereas in a study from Senegal the level of INFγ was higher in co-infected subjects and the increase of IL-10 was only observed in adults but not in children when considering schistosoma and malaria co-infection (Diallo et al. 2004). This evidence concerns the gene IL10 and coinfection.