Based on experience from clinical practice that has shown that LGESS is generally a hormonally-sensitive tumor with indolent growth, adjuvant progestin treatment is currently the most effective treatment for treatment of LGESS and should be considered as a routine adjuvant therapy for the treatment of ESS or recurrent ESS, particularly for those with strong positivity for PR staining (10,11). The gene discussed is PGR; the disease is endometrioid stromal sarcoma.