In addition, with regard to the expression of B7-H3 and B7-H1 in the tumor tissue, the results of the present study were similar to those reported by Lemke et al (16) and our previous study (27), which showed that the expression of B7-H3 and B7-H1 in glioma tissue was correlated with the glioma grade. Here, CD274 is linked to central nervous system cancer.