B7-H1 is expressed in hematopoietic malignancies, including leukemia, thymic neoplasms and multiple myeloma, as well as in the majority of types of solid human cancer, including breast, colon, esophageal, gastric, head and neck squamous cell, kidney, liver, lung, ovarian, pancreatic, salivary gland and urothelial carcinomas, as well as glioblastoma (tumor tissues only), Wilms’ tumor and melanoma (17–22). The gene discussed is CD274; the disease is neoplasm.