Immunohistochemical analysis revealed that the glandular epithelial cells were CK19- and CK5/6-positive, the myoepithelial cells were smooth muscle antibody-, smooth muscle myosin heavy chain- and S-100-positive and glial fibrillary acidic protein-negative, and the tumor cells were cluster of differentiation (CD)34-positive and estrogen receptor (ER)- and progesterone receptor (PR)-negative (Fig. 3). The gene discussed is ESR1; the disease is neoplasm.