KLK3 and metastatic malignant neoplasm in the lymph nodes: Furthermore, these associations were confirmed by Cox univariate analysis [PFS: hazard ratio (HR), 0.54; 95% confidence interval (CI), 0.33–0.87; P=0.012; and OS: HR, 0.44; 95% CI, 0.27–0.71; P=0.001] and multivariate analysis, with adjustments for age, Gleason score, serum PSA level, distant metastasis, and lymph node metastasis (PFS: HR, 0.37; 95% CI, 0.20–0.67; P=0.001; and OS: HR, 0.29; 95% CI, 0.15–0.57; P<0.001) (Table II).