However, abnormal NNMT expression has been identified in several types of tumors, including glioblastoma (16), stomach adenocarcinoma (17), papillary thyroid cancers (18), colorectal cancer (12), hepatocellular carcinoma (19), lung cancer (11) and renal cancer (20), suggesting that NNMT may have a significant role in cancer. This evidence concerns the gene NNMT and cancer.