Additionally, Leslie et al (21) reported that colorectal cancer cells become spindle-shaped following treatment with LY294002, a PI3K/Akt-specific inhibitor, an effect which was accompanied by a reduced expression of E-cadherin and increased invasiveness of the cells, further supporting the role of the PTEN/E-cadherin signaling axis in EMT. The gene discussed is PTEN; the disease is colorectal cancer.