A review of the literature identified that the immunohistochemical characteristics of HCC include positivity for the neurosecretory markers, CgA, Syn and NSE, and negativity for Hep Par-1 (OCH1E5), AFP, thyroid transcription factor-1, CDX2 and leukocyte common antigen. The gene discussed is NKX2-1; the disease is hepatocellular carcinoma.