As summarized in Table I, IRF8 protein expression was more frequently downregulated in male than in female patients, in smokers than in non-smokers, in non-adenocarcinomas than in adenocarcinomas, in stage IB-III than in stage IA, and in patients with wild-type EGFR than in those with mutated EGFR. Of the 94 patients, seven patients had recurrence of disease. This evidence concerns the gene IRF8 and adenocarcinoma.