In the last few years, a number of studies have focused on the alternate translocation in APL, for example t(5;17)(q35;q21) forming NPM/RARA, t(11;17)(q23;q21) producing PLF/RARA fusion and t(11;17)(q13;q21) generating NUMA/RARA, providing advanced insights into the pathogenesis of APL (3,6,7). The gene discussed is NPM1; the disease is acute promyelocytic leukemia.