GH1 and Myocardial fibrosis: Apart from the ability to stimulate GH secretion and to exert regulatory effects on appetite and metabolism, it has become increasingly evident that ghrelin has a number of effects on the cardiovascular system (10) via a GH-independent pathway, such as reducing myocardial oxygen consumption, anti-inflammatory action (9), inducing anti-myocardial apoptosis, inhibiting myocardial fibrosis (11) and suppressing the sympathetic nervous system (12,13).