NPPB and anemia (phenotype): This decrease in BNP levels could be associated with improvements in a number of aspects, including improvements in cardiac function as a result of increased oxygen supply to the heart, reduced load caused by the prevention of anemia-induced tachycardia and increased stroke volume, reduction in plasma volume and a reduction in the activity of the sympathetic and renin angiotensin-aldosterone system, which occurs in anemia (3,30).