Though the study by Zong et al revealed that Hcy was an independent risk factor of primary hypertension in the Kazakh population, it did not reveal that the CBS T833C mutations were associated with primary hypertension in the Kazakh population, which further demonstrates that a single factor and/or gene locus is responsible for hypertension, in particular, in the Kazakh population in Xinjiang. The gene discussed is CBS; the disease is essential hypertension.