Several studies showed that mice deficient for inflammasome components including NLRP3, ASC, and caspase-1 were highly susceptible to acute colitis induced by DSS, indicating the protective role of inflammasome in acute colitis (Allen et al., 2010; Dupaul-Chicoine et al., 2010; Hirota et al., 2011). The gene discussed is CASP1; the disease is colitis.