Using macrophage-specific KO mice, Morales et al. (2014) showed that mice with macrophage-specific deletion of GRP94/gp96 exhibited decreased colitis and inflammation-associated colon cancer induced by DSS/AOM, with reduced expression of inflammatory cytokines such as IL-6, IL-17, and IL-23. The gene discussed is HSP90B1; the disease is malignant colon neoplasm.