ITGAM and infection: CD11b+ DC isolated from infected C57BL/6 mice are productively infected and fail to activate naïve anti-MCMV CD8 T cells in ex vivo culture, suggesting that productive MCMV infection of CD11b+ DC in vivo compromises their ability to directly process and present endogenously synthesized viral antigens to CD8 T cells (Busche et al., 2013).