AGT and obesity due to melanocortin 4 receptor deficiency: Not only does adipose tissue have a local RAS (for review see Cassis et al., 2008; de Kloet et al., 2010; Frigolet et al., 2013) but serum levels of all the components of the RAS [renin, angiotensinogen (AGT), angiotensin (ANG) converting enzyme] are elevated in obesity (Cooper et al., 1998; Yasue et al., 2010).