AKT1 and schizophrenia: The same group had previously shown that atypical APDs increase Akt phosphorylation in cultured mammalian neurons (Lu et al., 2004; Lu and Dwyer, 2005), findings consistent with earlier suggestions (Dwyer et al., 2003) and human genetic studies implicating dysfunction of the PI3K/AKT pathway in schizophrenia (Emamian et al., 2004).