For example, it is noteworthy that human RyR genes, RYR1 and RYR3, are encoded at sites, 19q13 and 15q14–15, respectively, which have been implicated as risk loci for bipolar disorder in genome-wide association studies (Reif et al., 2004; Francks et al., 2010; Green et al., 2013). Here, RYR1 is linked to bipolar disorder.