ACO1 and Parkinson disease: The IRP1 gene (ACO1) has been associated with cutaneous malignant melanoma (Yang et al., 2010) and neuropathic pain in HIV-infected patients (Kallianpur et al., 2014), while the IRE-binding activity of IRP1 was reported to be increased in Friedreichs' ataxia (Lobmayr et al., 2005) and in Parkinson's disease (Faucheux et al., 2002).