To date, three isoforms of ApoE have been described (ɛ2, ɛ3, and ɛ4), and the ApoEɛ4 variant is considered to be one of the most relevant risk factors for AD (Corder et al., 1993; Zhu et al., 2012; Tai et al., 2014). This evidence concerns the gene APOE and Alzheimer disease.