The critical role of BACE as an Aβ-level modulator is no longer debated, and recent work has suggested the importance of understanding how BACE polymorphisms determine not only Down’s syndrome AD onset but also sporadic AD cases (Zhou et al., 2010; Mok et al., 2013; Natunen et al., 2013). This evidence concerns the gene BACE1 and Alzheimer disease.