A case in point is ADNFLE, epilepsy that can be caused by mutations either in the α-4, α-2 or β-2 subunits of the neuronal nicotinic acetylcholine receptor, encoded by the CHRNA4, CHRNA2, or CHRNB2 genes respectively, or by mutations in the Slack channel. The gene discussed is CHRNA4; the disease is autosomal dominant nocturnal frontal lobe epilepsy.