Increasing evidence supports this hypothesis: epilepsy patients who have profound intellectual disability carry mutations in the Slack-encoding KCNT1. More than a dozen different KCNT1 mutations have now been reported in the literature, in connection with three different types of seizures that occur in infancy or childhood, MMPSI, ADNFLE, and OS (Barcia et al., 2012; Heron et al., 2012; Martin et al., 2014). Here, KCNT1 is linked to autosomal dominant nocturnal frontal lobe epilepsy.