In a separate study, ER-positive breast cancer patients who relapsed after tamoxifen treatment had significantly increased levels of NOV [49], which further underscores the inverse relationship between NOV and hsa-mir-30c in breast cancer, as well as in our observations of low hsa-mir-30c in the ER positive cell line (MCF-7) and higher levels in the MDA-MB-231 cells which are ER negative.. Here, ESR1 is linked to breast cancer.