TLR4 and early-onset autosomal dominant Alzheimer disease: In particular, polymorphisms of TLR4 gene (NM-138554.1), and particularly the rs4986790 TLR4 polymorphism, have been associated with the risk for several CVDs and other age-related diseases (i.e., Alzheimer disease, prostate cancer, and diabetes), even if contrasting results have been reported [30, 32, 36, 43].