Interestingly, one of the interaction partners, Unc119, which was 7.5-fold enriched in the GA149-GFP immunoprecipitates, was previously identified through severely impaired locomotion in a C. elegans mutant and is required for axon development and maintenance [23, 30], which warranted further analysis in the context of ALS. The gene discussed is UNC119; the disease is amyotrophic lateral sclerosis.