However, analysis of cytokine profiles in the lungs of immunized, compared to mock-immunized mice demonstrated a gradual reduction in Th1-type cytokine (IL-2 and IL-12 p70), pro-inflammatory cytokine (IL-1α, IL-1β, IL-6, IL-17A and G-CSF) and chemokine (CCL2, CCL3 and CXCL1) production as the infection progressed. The gene discussed is CSF3; the disease is infection.