Here, we show that KCASP1Tg and KIL-18Tg mice with dermatitis have severe pathology in systemic organs other than the skin including aberrant remodeling of fatty and connective tissues, and extensive amyloid deposition with organ dysfunction, and that these abnormalities improved with the use of anti IL-1α/β antibodies. The gene discussed is IL1A; the disease is dermatitis.