Regarding markers ofmetabolic syndrome, NC showed a positive correlation with SBP, DBP, TG, plasma uricacid, GGT, and ALT and a negative correlation with HDL-cholesterol in pubertal females.A positive linear correlation was found between NC, SBP, DBP, plasma uric acid, and GGTin prepubertal males, while NC showed a positive linear correlation with SBP, DBP, LDL,TG, plasma uric acid, and GGT and a negative correlation with HDL in pubertal males.Regarding markers of IR, NC was positively correlated with insulin and HOMA1-IR inpubertal and prepubertal females. This evidence concerns the gene GPT and Down syndrome.