Although we saw increased pancreatic content of Reg3B, a marker of pancreatitis, by immunohistochemical analysis, with all three GLP-1 mimetics used in this study (Fig.3A–D), we did not observe increases in plasma amylase or lipase with administration of liraglutide and exendin-4 in conjunction with the high fat diet (Fig. 3E-F). This evidence concerns the gene GCG and pancreatitis.