However, SU11248 caused a significant reduction in constitutive levels of AKT and Stat3 phosphorylation of in all the fibrosarcoma cells (Figure 8d); after overnight incubation with SU11248, the phosphorylation levels of both AKT and Stat3 returned back to their original basal levels (data not shown). This evidence concerns the gene AKT1 and fibrosarcoma.