In murine FL5.12 cells, retroviral transformation by Bcr-Abl induced VEGF, FGF-2, HGF, IL-8, MMP2 and MMP9, but HGF production was Bcr-Abl-independent in CML, as it could not be blocked by imatinib [16,97]. The gene discussed is HGF; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.