In contrast to certain inflammation cytokines (IL-6, TNF-α), which depend on Bcr-Abl or JAK2V617F (Figure 5A), the autocrine production of HGF is independent from Bcr-Abl in CML, and independent from JAK2V617F in MPNs. This evidence concerns the gene TNF and chronic myelogenous leukemia, BCR-ABL1 positive.